Pharmaceutics

This course introduces the student to the technologies involved in pharmaceuticals development processes and their required pharmaceutics components or excipients. Students will learn the basic requirements of good manufacturing practices (GMP) followed worldwide for drug or pharmaceuticals development. The students will differentiate between the most common dosage forms, their routes of administrations, and the use of bioavailability and bioequivalence for formulations'92 assessments. The major classifications and pharmaceutical compounding of dosage forms will be covered, including; powders and granules, capsules, tablets (coating, disintegration, dissolution), solutions (solubility, polymorphism, crystal structure), polyphases systems (colloids, gels, suspension, emulsions, surface tension, surfactants, HLB), topical dosage forms (creams, ointments, absorption), and mucosal delivery (nasal, pulmonary, buccal). Stability and quality control studies of each dosage form will be addressed. The basic principles associated with pharmaceutical (extemporaneous) compounding will be explained. There will be laboratory sessions to provide general principles and hands-on experience in the preformulation, formulation, manufacturing, and quality control fields that are necessary in design, formulation, compounding and manufacturing of drug dosage forms.

This course will introduce students to the pharmaceutical aspects of drug delivery systems as well as alternative application sites with a view to optimize therapeutic effect. It will discuss selected modern formulation principles (applied as well as potential) theoretically and methodically to explain problems/issues concerning the optimization of absorption, selective transport and targeting as well as the properties and effect of excipients. The course will cover drug classes (small molecules, prodrugs, peptides, proteins, nucleotides, etc.); applicable delivery systems (solid dispersions, self-emulsifying systems, cyclodextrins, polymeric nanoparticles, liposomes, etc.) and administration routes (oral, IV, IM, topical, pulmonary, nasal, etc.). Students will learn the development and characterization of drug delivery systems, release models, transport and absorption studies in in vitro and in vivo models.