The "special topics" courses are offered for credit in emerging areas of life sciences and related fields. The subject matter or content may vary from term to term as indicated by that course's title and description. Special topics courses are intended to review recent development, discoveries, or to address specific issues or concepts within the field of study that are not covered in existing courses.
Stem cells and regenerative medicine.
Pluripotent stem cells are defined by their ability to self-renew and the capacity to differentiate into any cell type of the body. These cells hold great promise for novel therapeutic approaches to reinstate the functionally impaired tissues. Traditionally, embryonic stem cell research faced ethical and immunological challenges. However, with the generation of induced pluripotent stem cells (iPSCs) by Dr. Yamanaka in 2006 not only addressed these challenges, but also opened up new avenues in generation of patient specific stem cells and their therapeutic applications. These ease of iPSCs’generation and advancements in the guided differentiation have led to the use of these cells in a number of clinical trials spanning metabolic, cardiovascular, neurological, ophthalmic, immunological and hematological disorders. This course provides students with the understanding of stem cells, their types and the latest developments in the use of stem cells in studying a number of diseases including diabetes, heart diseases and neuronal disorders. Additionally, bioethical implications associated with the stem cells technology will be discussed.
In order to develop critical analysis of the literature, the students will write essays pertaining to aspects of stem cell signaling, stemness, and regenerative medicine and do presentation.
Epigenetics.
During the last decade it became obvious that epigenetic modifications of DNA and chromatin plays no less critical role in human development and diseases that DNA encoded genetic information inherited from the parents. Furthermore, recent studies confirmed that epigenetic state of DNA and chromatin might be passed through generations. Genetic analysis of common human disorders has revealed that development of various pathological conditions, such as metabolic diseases, cancer, neurological and psychological disorders depends on epigenetic status of relevant genes, rather than on their DNA sequences. These recent discoveries lead to a wide range of potential applications of epigenetics for analysis of etiology of some common human diseases and in development of new therapeutic strategies for their treatment.